相互作用
Milrinone + Olprinone
重症度: 重大
Milrinone and Olprinone: major interaction.
最終更新日
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概要
Both are phosphodiesterase-3 inhibitors with inotropic and vasodilating actions. Using them together duplicates therapy and increases the risk of hypotension and ventricular arrhythmias.
この相互作用をわかりやすく説明すると
Milrinone and Olprinone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Duplicate PDE-3 inhibition causing additive increases in cAMP, inotropy and vasodilation.
対処法
Avoid concurrent use; choose one PDE-3 inhibitor. If switching, stop the first before starting the second with monitoring of blood pressure and ECG.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、MilrinoneとOlprinoneの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Milrinoneのその他の相互作用
よくある質問
Can I take Milrinone with Olprinone?
MediHelp rates the interaction as major. Milrinone and Olprinone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are phosphodiesterase-3 inhibitors with inotropic and vasodilating actions. Using them together duplicates therapy and increases the risk of hypotension and ventricular arrhythmias.
How serious is the interaction between Milrinone and Olprinone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; choose one PDE-3 inhibitor. If switching, stop the first before starting the second with monitoring of blood pressure and ECG.
What other medicines interact with Milrinone?
MediHelp also lists interactions of Milrinone with, for example, Anagrelide, Cilostazol, Enoximone. The full list is on the Milrinone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
