相互作用
Aprepitant + Cobimetinib
重症度: 重大
Aprepitant and Cobimetinib: major interaction.
最終更新日
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概要
Aprepitant is a moderate CYP3A4 inhibitor and can raise cobimetinib concentrations. This increases the risk of cobimetinib toxicity such as rash, diarrhea, hemorrhage, liver injury and retinopathy.
この相互作用をわかりやすく説明すると
Aprepitant and Cobimetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Aprepitant belongs to Gastrointestinal Tract; Cobimetinib belongs to Oncology.
なぜ起こるのか
Aprepitant inhibits CYP3A4, reducing the metabolism of cobimetinib, a CYP3A substrate.
対処法
Avoid the combination and use an alternative antiemetic. If short-term use is unavoidable, reduce cobimetinib to 20 mg daily as labeled and monitor closely for toxicity.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AprepitantとCobimetinibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Aprepitantのその他の相互作用
Cobimetinibのその他の相互作用
よくある質問
Can I take Aprepitant with Cobimetinib?
MediHelp rates the interaction as major. Aprepitant and Cobimetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Aprepitant is a moderate CYP3A4 inhibitor and can raise cobimetinib concentrations. This increases the risk of cobimetinib toxicity such as rash, diarrhea, hemorrhage, liver injury and retinopathy.
How serious is the interaction between Aprepitant and Cobimetinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative antiemetic. If short-term use is unavoidable, reduce cobimetinib to 20 mg daily as labeled and monitor closely for toxicity.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
