相互作用
Cobimetinib + Efavirenz
重症度: 併用禁忌
Cobimetinib and Efavirenz: contraindicated interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Efavirenz induces CYP3A4 and can markedly lower cobimetinib exposure. This may lead to loss of antitumour efficacy.
この相互作用をわかりやすく説明すると
Cobimetinib and Efavirenz are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cobimetinib belongs to Oncology; Efavirenz belongs to Anti Virals.
なぜ起こるのか
Induction of CYP3A4-mediated metabolism of cobimetinib by efavirenz.
対処法
Avoid the combination and use an alternative antiretroviral without enzyme-inducing properties. If it cannot be avoided, seek oncology and HIV specialist input.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CobimetinibとEfavirenzの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Efavirenzのその他の相互作用
Cobimetinibのその他の相互作用
よくある質問
Can I take Cobimetinib with Efavirenz?
MediHelp rates the interaction as contraindicated. Cobimetinib and Efavirenz are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Efavirenz induces CYP3A4 and can markedly lower cobimetinib exposure. This may lead to loss of antitumour efficacy.
How serious is the interaction between Cobimetinib and Efavirenz?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative antiretroviral without enzyme-inducing properties. If it cannot be avoided, seek oncology and HIV specialist input.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Dienogest / estradiol valerate, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Efavirenz page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
