相互作用
Aprepitant + Mitotane
重症度: 重大
Aprepitant and Mitotane: major interaction.
最終更新日
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概要
Mitotane is a potent CYP3A4 inducer with a long half-life and can markedly reduce aprepitant concentrations. This may cause loss of antiemetic protection for weeks after mitotane exposure.
この相互作用をわかりやすく説明すると
Aprepitant and Mitotane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Aprepitant belongs to Gastrointestinal Tract; Mitotane belongs to Oncology.
なぜ起こるのか
Mitotane induces CYP3A4, increasing aprepitant clearance.
対処法
Avoid relying on aprepitant for emetic prophylaxis; use alternative antiemetics such as a 5-HT3 antagonist with dexamethasone adjusted for induction. Monitor for breakthrough vomiting.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AprepitantとMitotaneの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Aprepitantのその他の相互作用
Mitotaneのその他の相互作用
よくある質問
Can I take Aprepitant with Mitotane?
MediHelp rates the interaction as major. Aprepitant and Mitotane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mitotane is a potent CYP3A4 inducer with a long half-life and can markedly reduce aprepitant concentrations. This may cause loss of antiemetic protection for weeks after mitotane exposure.
How serious is the interaction between Aprepitant and Mitotane?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid relying on aprepitant for emetic prophylaxis; use alternative antiemetics such as a 5-HT3 antagonist with dexamethasone adjusted for induction. Monitor for breakthrough vomiting.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
