相互作用
Apixaban + Mitotane
重症度: 重大
Apixaban and Mitotane: major interaction.
最終更新日
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概要
Mitotane is a strong CYP3A4 inducer and can substantially lower apixaban concentrations, risking thrombosis or stroke from inadequate anticoagulation. The inducing effect persists for weeks after mitotane is stopped.
この相互作用をわかりやすく説明すると
Apixaban and Mitotane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apixaban belongs to Cardiovascular; Mitotane belongs to Oncology.
なぜ起こるのか
Induction of CYP3A4 (and likely P-gp) increases apixaban clearance.
対処法
Avoid the combination and choose an alternative anticoagulant such as low-molecular-weight heparin or a vitamin K antagonist with INR monitoring.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ApixabanとMitotaneの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Apixabanのその他の相互作用
Mitotaneのその他の相互作用
よくある質問
Can I take Apixaban with Mitotane?
MediHelp rates the interaction as major. Apixaban and Mitotane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mitotane is a strong CYP3A4 inducer and can substantially lower apixaban concentrations, risking thrombosis or stroke from inadequate anticoagulation. The inducing effect persists for weeks after mitotane is stopped.
How serious is the interaction between Apixaban and Mitotane?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an alternative anticoagulant such as low-molecular-weight heparin or a vitamin K antagonist with INR monitoring.
What other medicines interact with Apixaban?
MediHelp also lists interactions of Apixaban with, for example, Dabigatran, Defibrotide, Edoxaban. The full list is on the Apixaban page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
