相互作用
Aprepitant + Neratinib
重症度: 重大
Aprepitant and Neratinib: major interaction.
最終更新日
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概要
Aprepitant may raise neratinib concentrations via CYP3A4 inhibition. This may worsen neratinib toxicity, notably severe diarrhea and liver injury.
この相互作用をわかりやすく説明すると
Aprepitant and Neratinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Aprepitant belongs to Gastrointestinal Tract; Neratinib belongs to Oncology.
なぜ起こるのか
Aprepitant inhibits CYP3A4, the main route of neratinib metabolism.
対処法
Avoid moderate CYP3A4 inhibitors with neratinib and select an alternative antiemetic. If unavoidable, monitor for diarrhea and liver function.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AprepitantとNeratinibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Aprepitantのその他の相互作用
Neratinibのその他の相互作用
よくある質問
Can I take Aprepitant with Neratinib?
MediHelp rates the interaction as major. Aprepitant and Neratinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Aprepitant may raise neratinib concentrations via CYP3A4 inhibition. This may worsen neratinib toxicity, notably severe diarrhea and liver injury.
How serious is the interaction between Aprepitant and Neratinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid moderate CYP3A4 inhibitors with neratinib and select an alternative antiemetic. If unavoidable, monitor for diarrhea and liver function.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
