相互作用
Amiodarone + Neratinib
重症度: 重大
Amiodarone and Neratinib: major interaction.
最終更新日
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概要
Amiodarone may raise neratinib exposure through CYP3A4 and P-glycoprotein inhibition. This can worsen neratinib toxicities, particularly severe diarrhea and hepatotoxicity.
この相互作用をわかりやすく説明すると
Amiodarone and Neratinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Neratinib belongs to Oncology.
なぜ起こるのか
Amiodarone inhibits CYP3A4 and P-glycoprotein, increasing neratinib exposure.
対処法
Avoid coadministration where possible; if needed, monitor for diarrhea with antidiarrheal prophylaxis and check liver tests regularly.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmiodaroneとNeratinibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Amiodaroneのその他の相互作用
Neratinibのその他の相互作用
よくある質問
Can I take Amiodarone with Neratinib?
MediHelp rates the interaction as major. Amiodarone and Neratinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amiodarone may raise neratinib exposure through CYP3A4 and P-glycoprotein inhibition. This can worsen neratinib toxicities, particularly severe diarrhea and hepatotoxicity.
How serious is the interaction between Amiodarone and Neratinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration where possible; if needed, monitor for diarrhea with antidiarrheal prophylaxis and check liver tests regularly.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
