相互作用
Artemether + Cisapride
重症度: 併用禁忌
Artemether and Cisapride: contraindicated interaction.
最終更新日
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概要
Artemether, given with lumefantrine, can prolong the QT interval, and cisapride has a well-known risk of QT prolongation and torsades de pointes. Combined use may produce dangerous arrhythmias.
この相互作用をわかりやすく説明すると
Artemether and Cisapride are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
なぜ起こるのか
Additive QT prolongation; artemether may also modestly inhibit CYP3A4, which metabolizes cisapride.
対処法
Avoid concurrent use; withhold cisapride during antimalarial treatment and use another agent for the indication.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ArtemetherとCisaprideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Cisaprideのその他の相互作用
よくある質問
Can I take Artemether with Cisapride?
MediHelp rates the interaction as contraindicated. Artemether and Cisapride are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Artemether, given with lumefantrine, can prolong the QT interval, and cisapride has a well-known risk of QT prolongation and torsades de pointes. Combined use may produce dangerous arrhythmias.
How serious is the interaction between Artemether and Cisapride?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; withhold cisapride during antimalarial treatment and use another agent for the indication.
What other medicines interact with Cisapride?
MediHelp also lists interactions of Cisapride with, for example, Apomorphine, Azithromycin, Ceritinib. The full list is on the Cisapride page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
