相互作用
Artemether / lumefantrine + Phenytoin
重症度: 併用禁忌
Artemether / lumefantrine and Phenytoin: contraindicated interaction.
最終更新日
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概要
Phenytoin is a strong inducer of CYP3A4 and can markedly lower artemether and lumefantrine concentrations. This may lead to treatment failure of malaria and promote recrudescence or resistance.
この相互作用をわかりやすく説明すると
Artemether / lumefantrine and Phenytoin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
なぜ起こるのか
Induction of CYP3A4-mediated metabolism of artemether and lumefantrine by phenytoin.
対処法
Avoid the combination and choose an antimalarial or anticonvulsant that is not a strong enzyme inducer. If unavoidable, seek specialist advice and monitor parasitological response closely.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Artemether / lumefantrineとPhenytoinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Phenytoinのその他の相互作用
よくある質問
Can I take Artemether / lumefantrine with Phenytoin?
MediHelp rates the interaction as contraindicated. Artemether / lumefantrine and Phenytoin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phenytoin is a strong inducer of CYP3A4 and can markedly lower artemether and lumefantrine concentrations. This may lead to treatment failure of malaria and promote recrudescence or resistance.
How serious is the interaction between Artemether / lumefantrine and Phenytoin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an antimalarial or anticonvulsant that is not a strong enzyme inducer. If unavoidable, seek specialist advice and monitor parasitological response closely.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Bictegravir, Cabotegravir, Doravirine. The full list is on the Phenytoin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
