相互作用
Elbasvir / grazoprevir + Phenytoin
重症度: 併用禁忌
Elbasvir / grazoprevir and Phenytoin: contraindicated interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Phenytoin is expected to reduce elbasvir and grazoprevir concentrations, increasing the risk of hepatitis C treatment failure.
この相互作用をわかりやすく説明すると
Elbasvir / grazoprevir and Phenytoin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
なぜ起こるのか
Phenytoin induces CYP3A4 and P-glycoprotein, which clear both components.
対処法
Do not co-administer; use a non-inducing anticonvulsant or choose another HCV regimen compatible with phenytoin.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Elbasvir / grazoprevirとPhenytoinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Phenytoinのその他の相互作用
よくある質問
Can I take Elbasvir / grazoprevir with Phenytoin?
MediHelp rates the interaction as contraindicated. Elbasvir / grazoprevir and Phenytoin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phenytoin is expected to reduce elbasvir and grazoprevir concentrations, increasing the risk of hepatitis C treatment failure.
How serious is the interaction between Elbasvir / grazoprevir and Phenytoin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; use a non-inducing anticonvulsant or choose another HCV regimen compatible with phenytoin.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
