相互作用
Asciminib + Atorvastatin
重症度: 中等度
Asciminib and Atorvastatin: moderate interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Asciminib inhibits OATP1B and BCRP, which participate in atorvastatin hepatic uptake and efflux. Atorvastatin exposure may rise, increasing the risk of myopathy and rhabdomyolysis.
この相互作用をわかりやすく説明すると
Asciminib and Atorvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asciminib belongs to Oncology; Atorvastatin belongs to Cardiovascular.
なぜ起こるのか
Inhibition of OATP1B and BCRP transporters by asciminib raises atorvastatin systemic exposure.
対処法
Monitor for muscle pain, weakness and CK elevation, and consider a lower atorvastatin dose during asciminib therapy.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AsciminibとAtorvastatinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を7日間無料でお試し。カード登録不要。
Atorvastatinのその他の相互作用
Asciminibのその他の相互作用
よくある質問
Can I take Asciminib with Atorvastatin?
MediHelp rates the interaction as moderate. Asciminib and Atorvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asciminib inhibits OATP1B and BCRP, which participate in atorvastatin hepatic uptake and efflux. Atorvastatin exposure may rise, increasing the risk of myopathy and rhabdomyolysis.
How serious is the interaction between Asciminib and Atorvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle pain, weakness and CK elevation, and consider a lower atorvastatin dose during asciminib therapy.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
