相互作用
Atorvastatin + Cyclosporin
重症度: 重大
Atorvastatin and Cyclosporin: major interaction.
最終更新日
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概要
Cyclosporine inhibits OATP1B1 and other transporters, raising atorvastatin plasma levels many-fold. Myopathy and rhabdomyolysis become considerably more likely.
この相互作用をわかりやすく説明すると
Atorvastatin and Cyclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atorvastatin belongs to Cardiovascular; Cyclosporin belongs to Miscellaneous.
なぜ起こるのか
OATP1B1/CYP3A4 inhibition increases atorvastatin exposure
対処法
Avoid the combination; if a statin is needed use a low dose of pravastatin or fluvastatin and watch for muscle symptoms.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AtorvastatinとCyclosporinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Cyclosporinのその他の相互作用
Atorvastatinのその他の相互作用
よくある質問
Can I take Atorvastatin with Cyclosporin?
MediHelp rates the interaction as major. Atorvastatin and Cyclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine inhibits OATP1B1 and other transporters, raising atorvastatin plasma levels many-fold. Myopathy and rhabdomyolysis become considerably more likely.
How serious is the interaction between Atorvastatin and Cyclosporin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; if a statin is needed use a low dose of pravastatin or fluvastatin and watch for muscle symptoms.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
