相互作用
Atogepant + Clarithromycin
重症度: 中等度
Atogepant and Clarithromycin: moderate interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Clarithromycin increases atogepant exposure, which may heighten adverse effects such as nausea, constipation and fatigue.
この相互作用をわかりやすく説明すると
Atogepant and Clarithromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atogepant belongs to Central Nervous System; Clarithromycin belongs to Anti Bacterial.
なぜ起こるのか
Strong CYP3A4 inhibition (and possibly OATP/P-gp effects) reduces atogepant clearance.
対処法
Limit atogepant to 10 mg once daily while clarithromycin is co-administered and monitor tolerability.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AtogepantとClarithromycinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Clarithromycinのその他の相互作用
Atogepantのその他の相互作用
よくある質問
Can I take Atogepant with Clarithromycin?
MediHelp rates the interaction as moderate. Atogepant and Clarithromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clarithromycin increases atogepant exposure, which may heighten adverse effects such as nausea, constipation and fatigue.
How serious is the interaction between Atogepant and Clarithromycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit atogepant to 10 mg once daily while clarithromycin is co-administered and monitor tolerability.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
