相互作用
Atomoxetine + Procarbazine
重症度: 併用禁忌
Atomoxetine and Procarbazine: contraindicated interaction.
最終更新日
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概要
Procarbazine inhibits monoamine oxidase, and atomoxetine raises synaptic noradrenaline. The combination has led to hypertensive reactions, hyperthermia, rigidity and altered consciousness.
この相互作用をわかりやすく説明すると
Atomoxetine and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Atomoxetine belongs to Central Nervous System; Procarbazine belongs to Oncology.
なぜ起こるのか
MAO inhibition plus noradrenaline reuptake inhibition causes excessive adrenergic stimulation
対処法
Do not use together; wait at least 14 days after stopping a MAOI before starting atomoxetine, and 2 days the other way round.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、AtomoxetineとProcarbazineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Atomoxetineのその他の相互作用
Procarbazineのその他の相互作用
よくある質問
Can I take Atomoxetine with Procarbazine?
MediHelp rates the interaction as contraindicated. Atomoxetine and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Procarbazine inhibits monoamine oxidase, and atomoxetine raises synaptic noradrenaline. The combination has led to hypertensive reactions, hyperthermia, rigidity and altered consciousness.
How serious is the interaction between Atomoxetine and Procarbazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; wait at least 14 days after stopping a MAOI before starting atomoxetine, and 2 days the other way round.
What other medicines interact with Atomoxetine?
MediHelp also lists interactions of Atomoxetine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Atomoxetine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
