相互作用
Axicabtagene ciloleucel + Capecitabine
重症度: 重大
Axicabtagene ciloleucel and Capecitabine: major interaction.
最終更新日
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概要
Capecitabine can cause lymphopenia and myelosuppression, which may impair collection, expansion and persistence of CAR T cells. It also adds to the infection risk after CAR T therapy.
この相互作用をわかりやすく説明すると
Axicabtagene ciloleucel and Capecitabine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Axicabtagene ciloleucel belongs to Oncology; Capecitabine belongs to Oncology.
なぜ起こるのか
Cytotoxic myelosuppression and lymphodepletion may compromise CAR T-cell function and add to immunosuppression.
対処法
Avoid capecitabine in the window before leukapheresis and during CAR T recovery unless clearly needed. Coordinate timing with the CAR T team and monitor for infection and cytopenias.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Axicabtagene ciloleucelとCapecitabineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Capecitabineのその他の相互作用
Axicabtagene ciloleucelのその他の相互作用
よくある質問
Can I take Axicabtagene ciloleucel with Capecitabine?
MediHelp rates the interaction as major. Axicabtagene ciloleucel and Capecitabine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Capecitabine can cause lymphopenia and myelosuppression, which may impair collection, expansion and persistence of CAR T cells. It also adds to the infection risk after CAR T therapy.
How serious is the interaction between Axicabtagene ciloleucel and Capecitabine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid capecitabine in the window before leukapheresis and during CAR T recovery unless clearly needed. Coordinate timing with the CAR T team and monitor for infection and cytopenias.
What other medicines interact with Capecitabine?
MediHelp also lists interactions of Capecitabine with, for example, Adenovirus types 4 and 7 live, Arsenic trioxide, Brexucabtagene autoleucel. The full list is on the Capecitabine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
