相互作用
Axicabtagene ciloleucel + Azathioprine
重症度: 重大
Axicabtagene ciloleucel and Azathioprine: major interaction.
最終更新日
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概要
Azathioprine may impair T-cell function and reduce CAR-T cell expansion and efficacy. Concurrent immunosuppression also adds to infection risk after lymphodepletion.
この相互作用をわかりやすく説明すると
Axicabtagene ciloleucel and Azathioprine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Axicabtagene ciloleucel belongs to Oncology; Azathioprine belongs to Gastrointestinal Tract.
なぜ起こるのか
Immunosuppressive antimetabolite activity against lymphocytes may reduce CAR-T cell expansion and persistence.
対処法
Discontinue azathioprine before leukapheresis and infusion as advised by the treating CAR-T center. Monitor for infections if immunosuppression cannot be stopped.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Axicabtagene ciloleucelとAzathioprineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Azathioprineのその他の相互作用
Axicabtagene ciloleucelのその他の相互作用
よくある質問
Can I take Axicabtagene ciloleucel with Azathioprine?
MediHelp rates the interaction as major. Axicabtagene ciloleucel and Azathioprine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Azathioprine may impair T-cell function and reduce CAR-T cell expansion and efficacy. Concurrent immunosuppression also adds to infection risk after lymphodepletion.
How serious is the interaction between Axicabtagene ciloleucel and Azathioprine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Discontinue azathioprine before leukapheresis and infusion as advised by the treating CAR-T center. Monitor for infections if immunosuppression cannot be stopped.
What other medicines interact with Azathioprine?
MediHelp also lists interactions of Azathioprine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Febuxostat. The full list is on the Azathioprine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
