相互作用
Axicabtagene ciloleucel + Dacarbazine
重症度: 重大
Axicabtagene ciloleucel and Dacarbazine: major interaction.
最終更新日
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概要
Dacarbazine is a myelosuppressive agent. Given around the time of CAR T-cell therapy it may impair T-cell collection, expansion and persistence and adds to cytopenias and infection risk.
この相互作用をわかりやすく説明すると
Axicabtagene ciloleucel and Dacarbazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Axicabtagene ciloleucel belongs to Oncology; Dacarbazine belongs to Oncology.
なぜ起こるのか
Additive immunosuppression and myelosuppression, with possible cytotoxic effects on CAR T cells.
対処法
Avoid dacarbazine before leukapheresis and after infusion unless part of a planned protocol. Monitor blood counts and infections closely.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Axicabtagene ciloleucelとDacarbazineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Dacarbazineのその他の相互作用
Axicabtagene ciloleucelのその他の相互作用
よくある質問
Can I take Axicabtagene ciloleucel with Dacarbazine?
MediHelp rates the interaction as major. Axicabtagene ciloleucel and Dacarbazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dacarbazine is a myelosuppressive agent. Given around the time of CAR T-cell therapy it may impair T-cell collection, expansion and persistence and adds to cytopenias and infection risk.
How serious is the interaction between Axicabtagene ciloleucel and Dacarbazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid dacarbazine before leukapheresis and after infusion unless part of a planned protocol. Monitor blood counts and infections closely.
What other medicines interact with Dacarbazine?
MediHelp also lists interactions of Dacarbazine with, for example, Adenovirus types 4 and 7 live, Belatacept, Brexucabtagene autoleucel. The full list is on the Dacarbazine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
