相互作用
Azilsartan + Benazepril
重症度: 重大
Azilsartan and Benazepril: major interaction.
最終更新日
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概要
Combining an ACE inhibitor with an angiotensin receptor blocker gives dual renin-angiotensin system blockade. This raises the risk of hyperkalemia, hypotension and renal impairment without a proven added outcome benefit.
この相互作用をわかりやすく説明すると
Azilsartan and Benazepril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Azilsartan belongs to Cardiovascular; Benazepril belongs to Cardiovascular.
なぜ起こるのか
Additive pharmacodynamic inhibition of the renin-angiotensin-aldosterone system at two points, reducing aldosterone and glomerular efferent tone.
対処法
Avoid routine combination and use a single RAS blocker. If the combination is unavoidable, monitor serum potassium, creatinine and blood pressure closely.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AzilsartanとBenazeprilの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Benazeprilのその他の相互作用
Azilsartanのその他の相互作用
よくある質問
Can I take Azilsartan with Benazepril?
MediHelp rates the interaction as major. Azilsartan and Benazepril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an ACE inhibitor with an angiotensin receptor blocker gives dual renin-angiotensin system blockade. This raises the risk of hyperkalemia, hypotension and renal impairment without a proven added outcome benefit.
How serious is the interaction between Azilsartan and Benazepril?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine combination and use a single RAS blocker. If the combination is unavoidable, monitor serum potassium, creatinine and blood pressure closely.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
