相互作用
Baclofen + Buprenorphine long-acting
重症度: 重大
Baclofen and Buprenorphine long-acting: major interaction.
最終更新日
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概要
Baclofen with long-acting injectable buprenorphine can cause additive sedation and respiratory depression. The depot gives prolonged exposure, so the interaction cannot be quickly reversed by stopping the opioid.
この相互作用をわかりやすく説明すると
Baclofen and Buprenorphine long-acting can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Additive CNS and respiratory depression from opioid receptor partial agonism and GABA-B agonism.
対処法
Use only when other treatments are inadequate, titrating baclofen to the lowest effective dose. Monitor for sedation and respiratory depression, particularly after baclofen initiation or increases.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BaclofenとBuprenorphine long-actingの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Baclofenのその他の相互作用
よくある質問
Can I take Baclofen with Buprenorphine long-acting?
MediHelp rates the interaction as major. Baclofen and Buprenorphine long-acting can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Baclofen with long-acting injectable buprenorphine can cause additive sedation and respiratory depression. The depot gives prolonged exposure, so the interaction cannot be quickly reversed by stopping the opioid.
How serious is the interaction between Baclofen and Buprenorphine long-acting?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only when other treatments are inadequate, titrating baclofen to the lowest effective dose. Monitor for sedation and respiratory depression, particularly after baclofen initiation or increases.
What other medicines interact with Baclofen?
MediHelp also lists interactions of Baclofen with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Baclofen page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
