相互作用
Baclofen + Brexanolone
重症度: 重大
Baclofen and Brexanolone: major interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Brexanolone infusion causes excessive sedation and sudden loss of consciousness in some patients. Baclofen adds CNS depressant effects, which may increase the likelihood or depth of these events.
この相互作用をわかりやすく説明すると
Baclofen and Brexanolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Additive CNS depression, with brexanolone acting as a positive GABA-A modulator and baclofen as a GABA-B agonist.
対処法
Monitor continuously for sedation and hypoxia during the infusion as required by labeling, and consider reducing or holding baclofen during treatment. Interrupt the infusion if excessive sedation occurs.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BaclofenとBrexanoloneの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Baclofenのその他の相互作用
よくある質問
Can I take Baclofen with Brexanolone?
MediHelp rates the interaction as major. Baclofen and Brexanolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Brexanolone infusion causes excessive sedation and sudden loss of consciousness in some patients. Baclofen adds CNS depressant effects, which may increase the likelihood or depth of these events.
How serious is the interaction between Baclofen and Brexanolone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor continuously for sedation and hypoxia during the infusion as required by labeling, and consider reducing or holding baclofen during treatment. Interrupt the infusion if excessive sedation occurs.
What other medicines interact with Baclofen?
MediHelp also lists interactions of Baclofen with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Baclofen page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
