相互作用
Baricitinib + Tofacitinib
重症度: 併用禁忌
Baricitinib and Tofacitinib: contraindicated interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Two JAK inhibitors given together provide duplicate immunosuppression with no established added benefit. The risk of serious infection and other JAK-related adverse effects increases.
この相互作用をわかりやすく説明すると
Baricitinib and Tofacitinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Baricitinib belongs to Musculoskeletal; Tofacitinib belongs to Musculoskeletal.
なぜ起こるのか
Duplicate JAK inhibition causing additive immunosuppression.
対処法
Do not use two JAK inhibitors together; select a single agent. If switching, stop one before starting the other.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BaricitinibとTofacitinibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Tofacitinibのその他の相互作用
Baricitinibのその他の相互作用
よくある質問
Can I take Baricitinib with Tofacitinib?
MediHelp rates the interaction as contraindicated. Baricitinib and Tofacitinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Two JAK inhibitors given together provide duplicate immunosuppression with no established added benefit. The risk of serious infection and other JAK-related adverse effects increases.
How serious is the interaction between Baricitinib and Tofacitinib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use two JAK inhibitors together; select a single agent. If switching, stop one before starting the other.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Cladribine, Upadacitinib, Abatacept. The full list is on the Tofacitinib page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
