相互作用
Anti-thymocyte + Tofacitinib
重症度: 重大
Anti-thymocyte and Tofacitinib: major interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Tofacitinib is a Janus kinase inhibitor that impairs cytokine signalling, and anti-thymocyte globulin depletes T cells. Combined use markedly increases the risk of serious opportunistic and other infections.
この相互作用をわかりやすく説明すると
Anti-thymocyte and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Anti-thymocyte belongs to Miscellaneous; Tofacitinib belongs to Musculoskeletal.
なぜ起こるのか
Additive immunosuppression through T-cell depletion and JAK inhibition.
対処法
Avoid combining where possible; the label advises against use of tofacitinib with potent immunosuppressants. If combined, monitor closely for infection and use appropriate prophylaxis.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Anti-thymocyteとTofacitinibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Anti-thymocyteのその他の相互作用
- Anti-thymocyte + Bcg vaccine live 併用禁忌
- Anti-thymocyte + Influenza virus vaccine quadrivalent intranasal 併用禁忌
- Anti-thymocyte + Measles mumps and rubella vaccine live 併用禁忌
- Anti-thymocyte + Measles mumps rubella and varicella vaccine live 併用禁忌
- Anti-thymocyte + Measles vaccine 併用禁忌
- Anti-thymocyte + Rotavirus oral vaccine live 併用禁忌
Tofacitinibのその他の相互作用
よくある質問
Can I take Anti-thymocyte with Tofacitinib?
MediHelp rates the interaction as major. Anti-thymocyte and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tofacitinib is a Janus kinase inhibitor that impairs cytokine signalling, and anti-thymocyte globulin depletes T cells. Combined use markedly increases the risk of serious opportunistic and other infections.
How serious is the interaction between Anti-thymocyte and Tofacitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible; the label advises against use of tofacitinib with potent immunosuppressants. If combined, monitor closely for infection and use appropriate prophylaxis.
What other medicines interact with Anti-thymocyte?
MediHelp also lists interactions of Anti-thymocyte with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Anti-thymocyte page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
