相互作用
Basiliximab + Lisocabtagene maraleucel
重症度: 重大
Basiliximab and Lisocabtagene maraleucel: major interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Lisocabtagene maraleucel is a CAR T-cell therapy that depends on functional T-cell expansion, while basiliximab inhibits activated T cells through IL-2 receptor blockade. Combined use may reduce CAR T-cell efficacy and adds to infection risk in an already immunocompromised patient.
この相互作用をわかりやすく説明すると
Basiliximab and Lisocabtagene maraleucel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Basiliximab belongs to Miscellaneous; Lisocabtagene maraleucel belongs to Oncology.
なぜ起こるのか
Basiliximab blocks CD25 on activated T cells, which may impair CAR T-cell proliferation and persistence, with additive immunosuppression.
対処法
Avoid basiliximab around CAR T-cell infusion unless essential, and choose alternative approaches where possible. If used, monitor closely for infection and for loss of CAR T-cell response.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BasiliximabとLisocabtagene maraleucelの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Basiliximabのその他の相互作用
- Basiliximab + Bcg vaccine live 併用禁忌
- Basiliximab + Influenza virus vaccine quadrivalent intranasal 併用禁忌
- Basiliximab + Measles mumps and rubella vaccine 併用禁忌
- Basiliximab + Measles mumps and rubella vaccine live 併用禁忌
- Basiliximab + Measles mumps rubella and varicella vaccine live 併用禁忌
- Basiliximab + Measles vaccine 併用禁忌
Lisocabtagene maraleucelのその他の相互作用
よくある質問
Can I take Basiliximab with Lisocabtagene maraleucel?
MediHelp rates the interaction as major. Basiliximab and Lisocabtagene maraleucel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lisocabtagene maraleucel is a CAR T-cell therapy that depends on functional T-cell expansion, while basiliximab inhibits activated T cells through IL-2 receptor blockade. Combined use may reduce CAR T-cell efficacy and adds to infection risk in an already immunocompromised patient.
How serious is the interaction between Basiliximab and Lisocabtagene maraleucel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid basiliximab around CAR T-cell infusion unless essential, and choose alternative approaches where possible. If used, monitor closely for infection and for loss of CAR T-cell response.
What other medicines interact with Basiliximab?
MediHelp also lists interactions of Basiliximab with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Basiliximab page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
