相互作用
Azathioprine + Lisocabtagene maraleucel
重症度: 重大
Azathioprine and Lisocabtagene maraleucel: major interaction.
最終更新日
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概要
Azathioprine may impair CAR T-cell expansion and persistence, potentially reducing efficacy of lisocabtagene maraleucel. Together they also increase susceptibility to serious infection.
この相互作用をわかりやすく説明すると
Azathioprine and Lisocabtagene maraleucel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Azathioprine belongs to Gastrointestinal Tract; Lisocabtagene maraleucel belongs to Oncology.
なぜ起こるのか
Antimetabolite-driven lymphocyte suppression may blunt CAR T-cell proliferation, and the effects add to the immune deficiency caused by the therapy.
対処法
Avoid azathioprine around lymphodepletion and CAR T infusion unless essential, and follow the product labeling for washout. Monitor closely for infection and cytopenias if it must be used.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AzathioprineとLisocabtagene maraleucelの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Azathioprineのその他の相互作用
Lisocabtagene maraleucelのその他の相互作用
よくある質問
Can I take Azathioprine with Lisocabtagene maraleucel?
MediHelp rates the interaction as major. Azathioprine and Lisocabtagene maraleucel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Azathioprine may impair CAR T-cell expansion and persistence, potentially reducing efficacy of lisocabtagene maraleucel. Together they also increase susceptibility to serious infection.
How serious is the interaction between Azathioprine and Lisocabtagene maraleucel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid azathioprine around lymphodepletion and CAR T infusion unless essential, and follow the product labeling for washout. Monitor closely for infection and cytopenias if it must be used.
What other medicines interact with Azathioprine?
MediHelp also lists interactions of Azathioprine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Febuxostat. The full list is on the Azathioprine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
