相互作用
Bcg vaccine live + Dapsone
重症度: 重大
Bcg vaccine live and Dapsone: major interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Live BCG is a viable attenuated bacterium, and antibacterial drugs active against mycobacteria can kill the vaccine organisms and reduce the immune response. Dapsone has activity against mycobacteria, so vaccine efficacy may be impaired.
この相互作用をわかりやすく説明すると
Bcg vaccine live and Dapsone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Dapsone's antimycobacterial activity may inactivate the live attenuated BCG organisms, reducing vaccine take.
対処法
Defer BCG vaccination until dapsone therapy is finished, or revaccinate later if it was given during treatment. For intravesical BCG, avoid concurrent antimycobacterial therapy.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Bcg vaccine liveとDapsoneの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を7日間無料でお試し。カード登録不要。
Dapsoneのその他の相互作用
よくある質問
Can I take Bcg vaccine live with Dapsone?
MediHelp rates the interaction as major. Bcg vaccine live and Dapsone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Live BCG is a viable attenuated bacterium, and antibacterial drugs active against mycobacteria can kill the vaccine organisms and reduce the immune response. Dapsone has activity against mycobacteria, so vaccine efficacy may be impaired.
How serious is the interaction between Bcg vaccine live and Dapsone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Defer BCG vaccination until dapsone therapy is finished, or revaccinate later if it was given during treatment. For intravesical BCG, avoid concurrent antimycobacterial therapy.
What other medicines interact with Dapsone?
MediHelp also lists interactions of Dapsone with, for example, Primaquine, Apalutamide, Belzutifan. The full list is on the Dapsone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
