相互作用
Bosentan + Dapsone
重症度: 中等度
Bosentan and Dapsone: moderate interaction.
最終更新日
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概要
Bosentan induces CYP3A4 and CYP2C9 and may reduce dapsone concentrations. Reduced dapsone efficacy is possible, and both drugs can affect the liver.
この相互作用をわかりやすく説明すると
Bosentan and Dapsone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Dapsone belongs to Anti Bacterial.
なぜ起こるのか
Bosentan induces CYP3A4, increasing dapsone metabolism.
対処法
Monitor clinical response to dapsone and liver enzymes, as bosentan itself is hepatotoxic.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BosentanとDapsoneの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Dapsoneのその他の相互作用
Bosentanのその他の相互作用
よくある質問
Can I take Bosentan with Dapsone?
MediHelp rates the interaction as moderate. Bosentan and Dapsone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan induces CYP3A4 and CYP2C9 and may reduce dapsone concentrations. Reduced dapsone efficacy is possible, and both drugs can affect the liver.
How serious is the interaction between Bosentan and Dapsone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to dapsone and liver enzymes, as bosentan itself is hepatotoxic.
What other medicines interact with Dapsone?
MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Apalutamide. The full list is on the Dapsone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
