相互作用
Bcg vaccine live + Sirolimus
重症度: 併用禁忌
Bcg vaccine live and Sirolimus: contraindicated interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Sirolimus suppresses immune responses, so a live BCG vaccine may fail to produce protection and may cause disseminated BCG infection. Live vaccines are generally avoided in patients on immunosuppressive therapy.
この相互作用をわかりやすく説明すると
Bcg vaccine live and Sirolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
なぜ起こるのか
Sirolimus-mediated immunosuppression allows uncontrolled replication of the live attenuated organism and blunts the vaccine response.
対処法
Do not give live BCG vaccine during sirolimus therapy. Vaccinate before starting immunosuppression where feasible.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Bcg vaccine liveとSirolimusの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Sirolimusのその他の相互作用
よくある質問
Can I take Bcg vaccine live with Sirolimus?
MediHelp rates the interaction as contraindicated. Bcg vaccine live and Sirolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Sirolimus suppresses immune responses, so a live BCG vaccine may fail to produce protection and may cause disseminated BCG infection. Live vaccines are generally avoided in patients on immunosuppressive therapy.
How serious is the interaction between Bcg vaccine live and Sirolimus?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give live BCG vaccine during sirolimus therapy. Vaccinate before starting immunosuppression where feasible.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal, Ketoconazole. The full list is on the Sirolimus page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
