Drug interactions
Bcg vaccine live + Sirolimus
Severity: Contraindicated
Bcg vaccine live and Sirolimus: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sirolimus suppresses immune responses, so a live BCG vaccine may fail to produce protection and may cause disseminated BCG infection. Live vaccines are generally avoided in patients on immunosuppressive therapy.
What this interaction means in plain words
Bcg vaccine live and Sirolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Sirolimus-mediated immunosuppression allows uncontrolled replication of the live attenuated organism and blunts the vaccine response.
What to do
Do not give live BCG vaccine during sirolimus therapy. Vaccinate before starting immunosuppression where feasible.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
- Measles mumps and rubella vaccine + Sirolimus Contraindicated
Frequently asked questions
Can I take Bcg vaccine live with Sirolimus?
MediHelp rates the interaction as contraindicated. Bcg vaccine live and Sirolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Sirolimus suppresses immune responses, so a live BCG vaccine may fail to produce protection and may cause disseminated BCG infection. Live vaccines are generally avoided in patients on immunosuppressive therapy.
How serious is the interaction between Bcg vaccine live and Sirolimus?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give live BCG vaccine during sirolimus therapy. Vaccinate before starting immunosuppression where feasible.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal, Ketoconazole. The full list is on the Sirolimus page.
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