相互作用
Belladonna and opium + Chloral hydrate
重症度: 重大
Belladonna and opium and Chloral hydrate: major interaction.
最終更新日
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概要
The opium component is an opioid and combined with chloral hydrate can cause additive sedation and respiratory depression. The belladonna alkaloids add anticholinergic effects such as confusion in susceptible patients.
この相互作用をわかりやすく説明すると
Belladonna and opium and Chloral hydrate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Additive CNS and respiratory depression from opioid and sedative-hypnotic activity.
対処法
Avoid the combination where possible, or use the lowest doses and monitor respiratory rate and sedation closely. Warn patients and caregivers about signs of overdose.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Belladonna and opiumとChloral hydrateの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Chloral hydrateのその他の相互作用
よくある質問
Can I take Belladonna and opium with Chloral hydrate?
MediHelp rates the interaction as major. Belladonna and opium and Chloral hydrate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The opium component is an opioid and combined with chloral hydrate can cause additive sedation and respiratory depression. The belladonna alkaloids add anticholinergic effects such as confusion in susceptible patients.
How serious is the interaction between Belladonna and opium and Chloral hydrate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or use the lowest doses and monitor respiratory rate and sedation closely. Warn patients and caregivers about signs of overdose.
What other medicines interact with Chloral hydrate?
MediHelp also lists interactions of Chloral hydrate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Chloral hydrate page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
