相互作用
Calcium / magnesium / potassium / sodium oxybates + Chloral hydrate
重症度: 併用禁忌
Calcium / magnesium / potassium / sodium oxybates and Chloral hydrate: contraindicated interaction.
最終更新日
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概要
Both agents depress the central nervous system, and together they can cause profound sedation, respiratory depression, coma, or death. Oxybate labeling prohibits use with sedative hypnotics.
この相互作用をわかりやすく説明すると
Calcium / magnesium / potassium / sodium oxybates and Chloral hydrate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
なぜ起こるのか
Additive CNS and respiratory depression through pharmacodynamic synergism (GABAergic sedative plus GHB-receptor and GABA-B agonism).
対処法
Do not combine; stop chloral hydrate or use a non-sedating alternative before starting oxybate therapy.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Calcium / magnesium / potassium / sodium oxybatesとChloral hydrateの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Chloral hydrateのその他の相互作用
よくある質問
Can I take Calcium / magnesium / potassium / sodium oxybates with Chloral hydrate?
MediHelp rates the interaction as contraindicated. Calcium / magnesium / potassium / sodium oxybates and Chloral hydrate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both agents depress the central nervous system, and together they can cause profound sedation, respiratory depression, coma, or death. Oxybate labeling prohibits use with sedative hypnotics.
How serious is the interaction between Calcium / magnesium / potassium / sodium oxybates and Chloral hydrate?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; stop chloral hydrate or use a non-sedating alternative before starting oxybate therapy.
What other medicines interact with Chloral hydrate?
MediHelp also lists interactions of Chloral hydrate with, for example, Sodium oxybate, Alfentanil, Alprazolam. The full list is on the Chloral hydrate page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
