相互作用
Benzhydrocodone / acetaminophen + Tizanidine
重症度: 重大
Benzhydrocodone / acetaminophen and Tizanidine: major interaction.
最終更新日
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概要
Tizanidine is a sedating alpha-2 agonist and adds to opioid-induced CNS depression. The combination can cause profound sedation, respiratory depression and hypotension.
この相互作用をわかりやすく説明すると
Benzhydrocodone / acetaminophen and Tizanidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Additive CNS depression and hypotension from alpha-2 agonism and mu-opioid agonism.
対処法
Use together only when alternatives are inadequate, with the lowest effective doses. Monitor sedation, respiratory rate and blood pressure.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Benzhydrocodone / acetaminophenとTizanidineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Tizanidineのその他の相互作用
よくある質問
Can I take Benzhydrocodone / acetaminophen with Tizanidine?
MediHelp rates the interaction as major. Benzhydrocodone / acetaminophen and Tizanidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tizanidine is a sedating alpha-2 agonist and adds to opioid-induced CNS depression. The combination can cause profound sedation, respiratory depression and hypotension.
How serious is the interaction between Benzhydrocodone / acetaminophen and Tizanidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use together only when alternatives are inadequate, with the lowest effective doses. Monitor sedation, respiratory rate and blood pressure.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pefloxacin. The full list is on the Tizanidine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
