相互作用
Brompheniramine + Diamorphine
重症度: 重大
Brompheniramine and Diamorphine: major interaction.
最終更新日 出典: US FDA label
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Diamorphine (heroin) with a sedating antihistamine increases drowsiness and the risk of respiratory depression. This can be dangerous at higher opioid doses or in opioid-naive patients.
この相互作用をわかりやすく説明すると
Brompheniramine and Diamorphine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Additive CNS and respiratory depression via opioid agonism and H1 antagonism.
対処法
Use the lowest effective doses and monitor sedation and respiratory rate. Prefer a non-sedating antihistamine.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BrompheniramineとDiamorphineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を7日間無料でお試し。カード登録不要。
参考文献
Brompheniramineのその他の相互作用
よくある質問
Can I take Brompheniramine with Diamorphine?
MediHelp rates the interaction as major. Brompheniramine and Diamorphine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Diamorphine (heroin) with a sedating antihistamine increases drowsiness and the risk of respiratory depression. This can be dangerous at higher opioid doses or in opioid-naive patients.
How serious is the interaction between Brompheniramine and Diamorphine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and respiratory rate. Prefer a non-sedating antihistamine.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
