相互作用
Brompheniramine + Dipipanone
重症度: 重大
Brompheniramine and Dipipanone: major interaction.
最終更新日 出典: US FDA label
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概要
Dipipanone is a strong opioid, and a sedating antihistamine increases the risk of excessive sedation and respiratory depression.
この相互作用をわかりやすく説明すると
Brompheniramine and Dipipanone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Additive CNS and respiratory depression via opioid agonism and H1 antagonism.
対処法
Avoid if possible; otherwise use the lowest doses and monitor sedation and respiratory rate. Prefer a non-sedating antihistamine.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BrompheniramineとDipipanoneの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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参考文献
Brompheniramineのその他の相互作用
よくある質問
Can I take Brompheniramine with Dipipanone?
MediHelp rates the interaction as major. Brompheniramine and Dipipanone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dipipanone is a strong opioid, and a sedating antihistamine increases the risk of excessive sedation and respiratory depression.
How serious is the interaction between Brompheniramine and Dipipanone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise use the lowest doses and monitor sedation and respiratory rate. Prefer a non-sedating antihistamine.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
