相互作用
Buprenorphine buccal + Gabapentin
重症度: 重大
Buprenorphine buccal and Gabapentin: major interaction.
最終更新日
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概要
Gabapentin combined with an opioid such as buprenorphine can cause profound sedation and respiratory depression. Regulators have warned of this risk, especially in older patients and those with respiratory disease.
この相互作用をわかりやすく説明すると
Buprenorphine buccal and Gabapentin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Additive central nervous system and respiratory depression.
対処法
Use the lowest effective doses and monitor for sedation and respiratory depression, particularly at initiation and after dose increases. Consider dose reduction of gabapentin in at-risk patients.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Buprenorphine buccalとGabapentinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Gabapentinのその他の相互作用
よくある質問
Can I take Buprenorphine buccal with Gabapentin?
MediHelp rates the interaction as major. Buprenorphine buccal and Gabapentin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gabapentin combined with an opioid such as buprenorphine can cause profound sedation and respiratory depression. Regulators have warned of this risk, especially in older patients and those with respiratory disease.
How serious is the interaction between Buprenorphine buccal and Gabapentin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation and respiratory depression, particularly at initiation and after dose increases. Consider dose reduction of gabapentin in at-risk patients.
What other medicines interact with Gabapentin?
MediHelp also lists interactions of Gabapentin with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Gabapentin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
