相互作用
Amobarbital + Gabapentin
重症度: 重大
Amobarbital and Gabapentin: major interaction.
最終更新日
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概要
Combining a barbiturate with gabapentin increases sedation, dizziness and the risk of respiratory depression. The risk is greater in older patients, those with lung disease, and at higher doses.
この相互作用をわかりやすく説明すると
Amobarbital and Gabapentin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Gabapentin belongs to Central Nervous System.
なぜ起こるのか
Additive CNS depressant effects through pharmacodynamic synergism.
対処法
Use the lowest effective doses and monitor sedation and respiratory rate, especially at initiation and after dose increases.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmobarbitalとGabapentinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Amobarbitalのその他の相互作用
Gabapentinのその他の相互作用
よくある質問
Can I take Amobarbital with Gabapentin?
MediHelp rates the interaction as major. Amobarbital and Gabapentin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining a barbiturate with gabapentin increases sedation, dizziness and the risk of respiratory depression. The risk is greater in older patients, those with lung disease, and at higher doses.
How serious is the interaction between Amobarbital and Gabapentin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and respiratory rate, especially at initiation and after dose increases.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
