相互作用
Buprenorphine long-acting + Esketamine
重症度: 重大
Buprenorphine long-acting and Esketamine: major interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Esketamine and opioids can each cause sedation and dissociation, and together they may increase CNS and respiratory depression. Long-acting buprenorphine provides continuous exposure, so effects can overlap with each esketamine session.
この相互作用をわかりやすく説明すると
Buprenorphine long-acting and Esketamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Additive CNS and respiratory depression.
対処法
Monitor sedation, oxygen saturation, and breathing throughout the post-dose observation period. Use only when alternatives are inadequate.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Buprenorphine long-actingとEsketamineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を7日間無料でお試し。カード登録不要。
Esketamineのその他の相互作用
よくある質問
Can I take Buprenorphine long-acting with Esketamine?
MediHelp rates the interaction as major. Buprenorphine long-acting and Esketamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Esketamine and opioids can each cause sedation and dissociation, and together they may increase CNS and respiratory depression. Long-acting buprenorphine provides continuous exposure, so effects can overlap with each esketamine session.
How serious is the interaction between Buprenorphine long-acting and Esketamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, oxygen saturation, and breathing throughout the post-dose observation period. Use only when alternatives are inadequate.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
