相互作用
Amobarbital + Esketamine
重症度: 重大
Amobarbital and Esketamine: major interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Barbiturates are potent CNS depressants, and combining them with esketamine increases the risk of profound sedation and respiratory depression. Barbiturate use can also reduce the intended antidepressant effect.
この相互作用をわかりやすく説明すると
Amobarbital and Esketamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Esketamine belongs to Central Nervous System.
なぜ起こるのか
Additive CNS and respiratory depression via NMDA antagonism and GABA-A potentiation.
対処法
Avoid the combination where possible; if unavoidable, monitor sedation, oxygen saturation and respiration closely through the observation period.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmobarbitalとEsketamineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を7日間無料でお試し。カード登録不要。
Esketamineのその他の相互作用
Amobarbitalのその他の相互作用
よくある質問
Can I take Amobarbital with Esketamine?
MediHelp rates the interaction as major. Amobarbital and Esketamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Barbiturates are potent CNS depressants, and combining them with esketamine increases the risk of profound sedation and respiratory depression. Barbiturate use can also reduce the intended antidepressant effect.
How serious is the interaction between Amobarbital and Esketamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if unavoidable, monitor sedation, oxygen saturation and respiration closely through the observation period.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Esketamine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
