相互作用
Buprenorphine long-acting + Orphenadrin
重症度: 重大
Buprenorphine long-acting and Orphenadrin: major interaction.
最終更新日
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概要
Orphenadrine is sedating and anticholinergic, and long-acting injectable buprenorphine provides sustained opioid exposure. The combination may cause additive sedation and respiratory depression that persists because buprenorphine cannot be quickly withdrawn.
この相互作用をわかりやすく説明すると
Buprenorphine long-acting and Orphenadrin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Additive CNS depression.
対処法
Use only if alternatives are inadequate and keep the orphenadrine dose and duration to a minimum. Monitor for sedation and slowed breathing.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Buprenorphine long-actingとOrphenadrinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Orphenadrinのその他の相互作用
よくある質問
Can I take Buprenorphine long-acting with Orphenadrin?
MediHelp rates the interaction as major. Buprenorphine long-acting and Orphenadrin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Orphenadrine is sedating and anticholinergic, and long-acting injectable buprenorphine provides sustained opioid exposure. The combination may cause additive sedation and respiratory depression that persists because buprenorphine cannot be quickly withdrawn.
How serious is the interaction between Buprenorphine long-acting and Orphenadrin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only if alternatives are inadequate and keep the orphenadrine dose and duration to a minimum. Monitor for sedation and slowed breathing.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
