医薬品リファレンス
Orphenadrin
Orphenadrin is a medicine in the class musculoskeletal. It is used for muscle spasm.
- 薬効分類: Musculoskeletal
- 効能・効果: muscle spasm
最終更新日
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要点
- 薬効分類
- Musculoskeletal
- 一般的な剤形
- 錠剤, 注射剤
- 一般的な規格
- 30 mg/ml, 100 mg
- 既知の相互作用
- 225 (重大: 42 · 中等度: 159 · 軽度: 24)
- 商品名
- 2
- 国・市場
- 1
何に使われるか
作用のしくみ
May work through central atropine-like effect; anticholinergic activity in brain stem; has euphorigenic and analgesic properties
成人の通常用量（添付文書の要約）
Muscle Spasm & Pain: 100 mg PO q12hr OR 60 mg IV/IM q12hr (switch to PO as soon as possible)
妊娠と授乳
- 妊娠
- Unknown Long used without apparent harm, but safety is not established; animal studies found no hazard (UK label). Labels: use only if clearly needed, with caution. Prefer non-drug measures or paracetamol for muscle pain where possible.
- 授乳
- Unknown No published data; the UK label says milk amounts are unlikely to be significant at usual doses; use with caution. LactMed: its anticholinergic action might reduce milk supply; an alternative may be preferred. If used, watch milk supply and infant drowsiness.
報告されている副作用
- Drowsiness
- Dry mouth
- Lightheadedness
- Tachycardia
- Urinary retention
- Weakness
禁忌
- Hypersensitivity
- Narrow-angle glaucoma
- Pyloric/duodenal obstruction, BPH, stenosing peptic ulcers, cardiospasm (mega-esophagus), myasthenia gravis, obstructive uropathy, paralytic ileus, ulcerative colitis, toxic megacolon, achalasia
注意が必要な方
- Contraindicated in Pyloric/duodenal obstruction, BPH, and stenosing peptic ulcers.
- Safety of long-term therapy not established; if orphenadrine is prescribed for prolonged use, periodic monitoring of blood, urine and liver function is recommended
- Some patients may experience transient episodes of light-headedness, dizziness or syncope.
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (225)
- Alfentanil + Orphenadrin Major
- Amobarbital + Orphenadrin Major
- Benzhydrocodone / acetaminophen + Orphenadrin Major
- Brexanolone + Orphenadrin Major
- Buprenorphine + Orphenadrin Major
- Buprenorphine buccal + Orphenadrin Major
- Buprenorphine long-acting + Orphenadrin Major
- Buprenorphine subdermal implant + Orphenadrin Major
- Buprenorphine transdermal + Orphenadrin Major
- Calcium / magnesium / potassium / sodium oxybates + Orphenadrin Major
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Orphenadrinの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Paediatric dosing
- Dosing in older adults
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
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同じ分類のほかの薬剤
よくある質問
What is Orphenadrin used for?
Orphenadrin is a medicine in the class musculoskeletal. It is used for Muscle spasm, Pain management.
What side effects have been reported with Orphenadrin?
Drowsiness, Dry mouth, Lightheadedness, Tachycardia, Urinary retention, Weakness.
Can Orphenadrin be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Long used without apparent harm, but safety is not established; animal studies found no hazard (UK label). Labels: use only if clearly needed, with caution. Prefer non-drug measures or paracetamol for muscle pain where possible. Breastfeeding: Unknown. No published data; the UK label says milk amounts are unlikely to be significant at usual doses; use with caution. LactMed: its anticholinergic action might reduce milk supply; an alternative may be preferred. If used, watch milk supply and infant drowsiness.
What does Orphenadrin interact with?
MediHelp lists 225 known interactions for Orphenadrin. Major: 42 · Moderate: 159 · Minor: 24. The most serious include Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
