相互作用
Buprenorphine subdermal implant + Dantrolene
重症度: 重大
Buprenorphine subdermal implant and Dantrolene: major interaction.
最終更新日
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概要
Dantrolene causes drowsiness and generalized muscle weakness, and buprenorphine adds opioid sedation and respiratory depression. Combined use may lead to excessive sedation and breathing problems.
この相互作用をわかりやすく説明すると
Buprenorphine subdermal implant and Dantrolene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Additive central nervous system and respiratory depression from buprenorphine with dantrolene's sedation and muscle weakness.
対処法
Use together only when alternatives are inadequate, and monitor for sedation and respiratory depression. Reduce dantrolene dose if excessive drowsiness occurs.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Buprenorphine subdermal implantとDantroleneの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Dantroleneのその他の相互作用
よくある質問
Can I take Buprenorphine subdermal implant with Dantrolene?
MediHelp rates the interaction as major. Buprenorphine subdermal implant and Dantrolene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dantrolene causes drowsiness and generalized muscle weakness, and buprenorphine adds opioid sedation and respiratory depression. Combined use may lead to excessive sedation and breathing problems.
How serious is the interaction between Buprenorphine subdermal implant and Dantrolene?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use together only when alternatives are inadequate, and monitor for sedation and respiratory depression. Reduce dantrolene dose if excessive drowsiness occurs.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine transdermal. The full list is on the Dantrolene page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
