Drug interactions
Buprenorphine subdermal implant + Dantrolene
Severity: Major
Buprenorphine subdermal implant and Dantrolene: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dantrolene causes drowsiness and generalized muscle weakness, and buprenorphine adds opioid sedation and respiratory depression. Combined use may lead to excessive sedation and breathing problems.
What this interaction means in plain words
Buprenorphine subdermal implant and Dantrolene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive central nervous system and respiratory depression from buprenorphine with dantrolene's sedation and muscle weakness.
What to do
Use together only when alternatives are inadequate, and monitor for sedation and respiratory depression. Reduce dantrolene dose if excessive drowsiness occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dantrolene
Frequently asked questions
Can I take Buprenorphine subdermal implant with Dantrolene?
MediHelp rates the interaction as major. Buprenorphine subdermal implant and Dantrolene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dantrolene causes drowsiness and generalized muscle weakness, and buprenorphine adds opioid sedation and respiratory depression. Combined use may lead to excessive sedation and breathing problems.
How serious is the interaction between Buprenorphine subdermal implant and Dantrolene?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use together only when alternatives are inadequate, and monitor for sedation and respiratory depression. Reduce dantrolene dose if excessive drowsiness occurs.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine transdermal. The full list is on the Dantrolene page.
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