相互作用
Bupropion-naltrexone + Linezolid
重症度: 併用禁忌
Bupropion-naltrexone and Linezolid: contraindicated interaction.
最終更新日
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概要
Linezolid is a reversible nonselective MAO inhibitor, and bupropion is contraindicated with MAO inhibitors because of the risk of hypertensive reactions and neurotoxicity. Serotonergic or noradrenergic excess can occur.
この相互作用をわかりやすく説明すると
Bupropion-naltrexone and Linezolid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Bupropion-naltrexone belongs to Miscellaneous; Linezolid belongs to Anti Bacterial.
なぜ起こるのか
MAO inhibition by linezolid combined with bupropion's dopaminergic and noradrenergic reuptake inhibition causes catecholamine excess and possible serotonergic toxicity.
対処法
Do not co-administer; use an alternative antibiotic. If linezolid is urgent, stop bupropion-naltrexone and monitor closely, and avoid restarting it until at least 24 hours after the last linezolid dose.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Bupropion-naltrexoneとLinezolidの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Bupropion-naltrexoneのその他の相互作用
Linezolidのその他の相互作用
よくある質問
Can I take Bupropion-naltrexone with Linezolid?
MediHelp rates the interaction as contraindicated. Bupropion-naltrexone and Linezolid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Linezolid is a reversible nonselective MAO inhibitor, and bupropion is contraindicated with MAO inhibitors because of the risk of hypertensive reactions and neurotoxicity. Serotonergic or noradrenergic excess can occur.
How serious is the interaction between Bupropion-naltrexone and Linezolid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; use an alternative antibiotic. If linezolid is urgent, stop bupropion-naltrexone and monitor closely, and avoid restarting it until at least 24 hours after the last linezolid dose.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
