相互作用
Bupropion-naltrexone + Rasagiline
重症度: 併用禁忌
Bupropion-naltrexone and Rasagiline: contraindicated interaction.
最終更新日
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概要
Rasagiline (an irreversible MAO-B inhibitor) slows catecholamine breakdown, while bupropion blocks reuptake of dopamine and noradrenaline. The combination can produce hypertensive crisis, agitation and seizures; labelling for bupropion prohibits concurrent MAOI therapy.
この相互作用をわかりやすく説明すると
Bupropion-naltrexone and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Bupropion-naltrexone belongs to Miscellaneous; Rasagiline belongs to Central Nervous System.
なぜ起こるのか
MAO inhibition combined with dopamine and noradrenaline reuptake inhibition causes excess catecholamine activity
対処法
Do not use together. Wait at least 14 days after stopping rasagiline before starting the other drug; allow at least a week after stopping bupropion before starting an MAOI.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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アカウントを作成してPro+トライアルを始めると、Bupropion-naltrexoneとRasagilineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Bupropion-naltrexoneのその他の相互作用
Rasagilineのその他の相互作用
よくある質問
Can I take Bupropion-naltrexone with Rasagiline?
MediHelp rates the interaction as contraindicated. Bupropion-naltrexone and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rasagiline (an irreversible MAO-B inhibitor) slows catecholamine breakdown, while bupropion blocks reuptake of dopamine and noradrenaline. The combination can produce hypertensive crisis, agitation and seizures; labelling for bupropion prohibits concurrent MAOI therapy.
How serious is the interaction between Bupropion-naltrexone and Rasagiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Wait at least 14 days after stopping rasagiline before starting the other drug; allow at least a week after stopping bupropion before starting an MAOI.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
