相互作用
Buspirone + Selegiline transdermal
重症度: 併用禁忌
Buspirone and Selegiline transdermal: contraindicated interaction.
最終更新日
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概要
Buspirone given with a monoamine oxidase inhibitor has been associated with marked elevations in blood pressure. Selegiline at antidepressant transdermal doses inhibits both MAO isoenzymes, so the risk is relevant and buspirone labeling prohibits MAOI use.
この相互作用をわかりやすく説明すると
Buspirone and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
なぜ起こるのか
MAO inhibition combined with buspirone's serotonergic and dopaminergic activity produces a pharmacodynamic effect leading to hypertensive reactions; the exact mechanism is not fully established.
対処法
Avoid concurrent use; allow a washout of at least 2 weeks after stopping an MAOI before starting buspirone, and the reverse for selegiline.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BuspironeとSelegiline transdermalの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Buspironeのその他の相互作用
よくある質問
Can I take Buspirone with Selegiline transdermal?
MediHelp rates the interaction as contraindicated. Buspirone and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Buspirone given with a monoamine oxidase inhibitor has been associated with marked elevations in blood pressure. Selegiline at antidepressant transdermal doses inhibits both MAO isoenzymes, so the risk is relevant and buspirone labeling prohibits MAOI use.
How serious is the interaction between Buspirone and Selegiline transdermal?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; allow a washout of at least 2 weeks after stopping an MAOI before starting buspirone, and the reverse for selegiline.
What other medicines interact with Buspirone?
MediHelp also lists interactions of Buspirone with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Buspirone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
