相互作用
Busulfan + Itraconazole
重症度: 重大
Busulfan and Itraconazole: major interaction.
最終更新日
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概要
Itraconazole can decrease busulfan clearance and raise its exposure. This may increase myelosuppression and hepatic veno-occlusive disease, which is of particular concern in transplant conditioning.
この相互作用をわかりやすく説明すると
Busulfan and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Busulfan belongs to Oncology; Itraconazole belongs to Anti Fungals.
なぜ起こるのか
Itraconazole inhibits CYP3A4 and glutathione-related busulfan metabolism, reducing busulfan clearance.
対処法
Monitor busulfan levels where available and adjust the dose accordingly. Watch blood counts and liver function closely.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BusulfanとItraconazoleの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Itraconazoleのその他の相互作用
Busulfanのその他の相互作用
よくある質問
Can I take Busulfan with Itraconazole?
MediHelp rates the interaction as major. Busulfan and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Itraconazole can decrease busulfan clearance and raise its exposure. This may increase myelosuppression and hepatic veno-occlusive disease, which is of particular concern in transplant conditioning.
How serious is the interaction between Busulfan and Itraconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor busulfan levels where available and adjust the dose accordingly. Watch blood counts and liver function closely.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
