相互作用
Busulfan + Cyclophosphamide
重症度: 重大
Busulfan and Cyclophosphamide: major interaction.
最終更新日
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概要
Both agents are myelosuppressive alkylators, and together they markedly increase marrow toxicity. Busulfan given shortly before cyclophosphamide may also alter cyclophosphamide metabolism and increase hepatic toxicity such as veno-occlusive disease.
この相互作用をわかりやすく説明すると
Busulfan and Cyclophosphamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Busulfan belongs to Oncology; Cyclophosphamide belongs to Oncology.
なぜ起こるのか
Additive myelosuppression, with busulfan depleting glutathione and competing for hepatic metabolism of cyclophosphamide.
対処法
Use only in planned regimens with established sequencing and doses, and monitor blood counts and liver function closely. Allow an interval between busulfan and cyclophosphamide as specified in the protocol.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BusulfanとCyclophosphamideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Cyclophosphamideのその他の相互作用
Busulfanのその他の相互作用
よくある質問
Can I take Busulfan with Cyclophosphamide?
MediHelp rates the interaction as major. Busulfan and Cyclophosphamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents are myelosuppressive alkylators, and together they markedly increase marrow toxicity. Busulfan given shortly before cyclophosphamide may also alter cyclophosphamide metabolism and increase hepatic toxicity such as veno-occlusive disease.
How serious is the interaction between Busulfan and Cyclophosphamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only in planned regimens with established sequencing and doses, and monitor blood counts and liver function closely. Allow an interval between busulfan and cyclophosphamide as specified in the protocol.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
