相互作用
Cabotegravir + Phenobarbitone
重症度: 併用禁忌
Cabotegravir and Phenobarbitone: contraindicated interaction.
最終更新日
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概要
Phenobarbital is expected to reduce cabotegravir exposure to subtherapeutic levels. This risks virologic failure and resistance, especially with long-acting formulations that cannot be quickly adjusted.
この相互作用をわかりやすく説明すると
Cabotegravir and Phenobarbitone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cabotegravir belongs to Anti Virals; Phenobarbitone belongs to Central Nervous System.
なぜ起こるのか
Phenobarbital induces UGT1A1 and other metabolic enzymes, increasing cabotegravir clearance.
対処法
Avoid the combination and use an alternative anticonvulsant or antiretroviral. Account for prolonged induction after phenobarbital is discontinued.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、CabotegravirとPhenobarbitoneの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Cabotegravirのその他の相互作用
Phenobarbitoneのその他の相互作用
よくある質問
Can I take Cabotegravir with Phenobarbitone?
MediHelp rates the interaction as contraindicated. Cabotegravir and Phenobarbitone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phenobarbital is expected to reduce cabotegravir exposure to subtherapeutic levels. This risks virologic failure and resistance, especially with long-acting formulations that cannot be quickly adjusted.
How serious is the interaction between Cabotegravir and Phenobarbitone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative anticonvulsant or antiretroviral. Account for prolonged induction after phenobarbital is discontinued.
What other medicines interact with Cabotegravir?
MediHelp also lists interactions of Cabotegravir with, for example, Apalutamide, Carbamazepine, Oxcarbazepine. The full list is on the Cabotegravir page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
