相互作用
Apalutamide + Cabotegravir
重症度: 併用禁忌
Apalutamide and Cabotegravir: contraindicated interaction.
最終更新日
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概要
Apalutamide induces UGT1A1 and other enzymes, lowering cabotegravir concentrations, particularly with long-acting injectable cabotegravir. This risks loss of virologic response and integrase resistance.
この相互作用をわかりやすく説明すると
Apalutamide and Cabotegravir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Apalutamide belongs to Endocrine; Cabotegravir belongs to Anti Virals.
なぜ起こるのか
Apalutamide induces UGT1A1 (and UGT1A9), increasing cabotegravir glucuronidation.
対処法
Do not coadminister; use an alternative antiandrogen or antiretroviral. Monitor HIV RNA if exposure occurred.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ApalutamideとCabotegravirの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Apalutamideのその他の相互作用
Cabotegravirのその他の相互作用
よくある質問
Can I take Apalutamide with Cabotegravir?
MediHelp rates the interaction as contraindicated. Apalutamide and Cabotegravir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Apalutamide induces UGT1A1 and other enzymes, lowering cabotegravir concentrations, particularly with long-acting injectable cabotegravir. This risks loss of virologic response and integrase resistance.
How serious is the interaction between Apalutamide and Cabotegravir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; use an alternative antiandrogen or antiretroviral. Monitor HIV RNA if exposure occurred.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cobicistat, Doravirine, Elbasvir / grazoprevir. The full list is on the Apalutamide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
