相互作用
Canagliflozin-metformin + Contrast media
重症度: 重大
Canagliflozin-metformin and Contrast media: major interaction.
最終更新日
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概要
Iodinated contrast can cause acute kidney injury, which reduces metformin elimination and leads to accumulation. This increases the risk of metformin-associated lactic acidosis, especially in patients with reduced renal function.
この相互作用をわかりやすく説明すると
Canagliflozin-metformin and Contrast media can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Contrast-induced reduction in renal function lowers renal clearance of metformin, causing accumulation.
対処法
Hold metformin at the time of or before the procedure in patients with eGFR 30-60, liver disease, alcoholism, heart failure, or intra-arterial contrast. Re-check renal function 48 hours afterward and restart only if it is stable.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Canagliflozin-metforminとContrast mediaの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Canagliflozin-metforminのその他の相互作用
よくある質問
Can I take Canagliflozin-metformin with Contrast media?
MediHelp rates the interaction as major. Canagliflozin-metformin and Contrast media can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Iodinated contrast can cause acute kidney injury, which reduces metformin elimination and leads to accumulation. This increases the risk of metformin-associated lactic acidosis, especially in patients with reduced renal function.
How serious is the interaction between Canagliflozin-metformin and Contrast media?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold metformin at the time of or before the procedure in patients with eGFR 30-60, liver disease, alcoholism, heart failure, or intra-arterial contrast. Re-check renal function 48 hours afterward and restart only if it is stable.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Diatrizoate, Diatrizoate meglumine / diatrizoate, Diazoxide. The full list is on the Canagliflozin-metformin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
