相互作用
Canagliflozin-metformin + Ethiodized oil
重症度: 重大
Canagliflozin-metformin and Ethiodized oil: major interaction.
最終更新日
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概要
Ethiodized oil is an iodinated contrast agent. When given intravascularly (for example lymphography or chemoembolization) it may impair renal function and indirectly promote metformin accumulation and lactic acidosis.
この相互作用をわかりやすく説明すると
Canagliflozin-metformin and Ethiodized oil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Contrast-related renal impairment reduces metformin excretion, leading to accumulation.
対処法
Withhold metformin around intravascular administration in patients with renal impairment or high risk, and restart after confirming stable renal function about 48 hours later.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Canagliflozin-metforminとEthiodized oilの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Canagliflozin-metforminのその他の相互作用
よくある質問
Can I take Canagliflozin-metformin with Ethiodized oil?
MediHelp rates the interaction as major. Canagliflozin-metformin and Ethiodized oil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ethiodized oil is an iodinated contrast agent. When given intravascularly (for example lymphography or chemoembolization) it may impair renal function and indirectly promote metformin accumulation and lactic acidosis.
How serious is the interaction between Canagliflozin-metformin and Ethiodized oil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Withhold metformin around intravascular administration in patients with renal impairment or high risk, and restart after confirming stable renal function about 48 hours later.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
